01Check the other end first
That the PC or sending device is switched on, with the transfer software open, the correct port selected and the file ready to send. A large share of these alarms is resolved right here, especially if somebody changed PC, updated the system or moved the adapter.
02Compare the settings on both sides, one by one
Baud rate, data bits, parity, stop bits and flow control have to match exactly. Write them down from both ends on a piece of paper and compare. At the control, also check that the selected channel is the one that is wired.
03Check the cable and its connectors
That it is properly plugged in at both ends with no strain, and that it is the right cable for this machine; not all serial cables carry the same signals. If you have another cable known to be good, swapping it is the fastest test. Long cables run through the shop next to power lines pick up noise and fail intermittently.
04Lower the baud rate
If the transfer starts and cuts off halfway, or corrupt characters arrive, try lowering the rate at both ends. A link that fails at high speed and works at low speed is telling you there is noise or a cable in poor condition, even if it lets you work for now.
05Try the other direction
If receiving fails, try sending a small program from the control to the PC. If output works and input does not, the problem is narrowed down. If both directions fail, look at cable and settings before anything else.
06If everything matches and it still fails, it is a maintenance job
With settings verified, the cable proven and the other end working, what is left is the control's board or port. That is a maintenance diagnosis. In the meantime, if the machine accepts a memory card or USB, use that as an alternative so production does not stop.